Vineet Menachery, a coronavirologist at the University of Texas Medical Branch talked to Katherine Wu about variants improving their ability to resist interferons. “There’s a domino effect,” Menachery said. Wu wrote: “More cells get infected; antibody and T-cell responses hang back, even as viral particles continue to spread. Eventually, the body may get wise and try to catch up. But by then, it may be too late. The brunt of viral replication might be over, leaving the immune frenzy to misdirect much of its havoc onto our own tissues instead.”